Associate Director/Sr. Manager, Health Economics & Outcomes Research-Oncology

Position Summary

We are seeking a strategic, analytical, and highly collaborative leader to serve as our

Associate Director/Senior Manager of Health Economics & Outcomes Research

(HEOR) Oncology. In this high-impact role, you will lead the development and execution

of health economic and outcomes evidence demonstrating the clinical and economic

value of Natera’s precision molecular diagnostic technologies across oncology and

emerging indications.

You will develop health economic models, generate real-world and clinical-trial

evidence, lead HEOR publication initiatives, and translate complex clinical and

economic data into compelling evidence supporting market access, reimbursement,

payer adoption, clinical adoption, and commercialization. Working across Medical

Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing,

Regulatory, and Business Development, you will help integrate HEOR evidence

throughout the product lifecycle—from clinical development and evidence generation

through publication, reimbursement, and payer adoption.

This is a strategic role for an experienced HEOR professional who combines strong

technical capabilities with scientific communication, business acumen, and the ability to

influence cross-functional evidence strategy.

Why Join Us

At Natera, you will have the opportunity to shape the economic evidence strategy

supporting innovative precision diagnostics and biomarker-guided approaches to patient

care. You will work at the intersection of clinical evidence, health economics, market

access, and commercialization, translating clinical innovation into measurable value for

patients, providers, health systems, and payers.

You will collaborate with internal leaders, investigators, key opinion leaders, and

external research partners to generate evidence capable of influencing reimbursement

decisions, clinical adoption, health technology assessments, and healthcare policy

across U.S. and global markets.

Key Responsibilities

 Health Economic Modeling & Value Demonstration: Lead the development,

validation, and application of health economic models, including budget impact,

cost-effectiveness, cost-utility, cost-consequence, ROI, decision-tree,

Markov/state-transition, partitioned-survival, and other economic models.

Develop scenario and sensitivity analyses that quantify the clinical and economic

value of precision diagnostics across different payer and healthcare-system

perspectives.

 Clinical Development & HEOR Evidence Strategy: Partner with Clinical

Development, Medical Affairs, Biostatistics, and other cross-functional teams to

integrate HEOR objectives into prospective clinical studies, including healthcare

resource utilization, economic endpoints, patient-reported outcomes, quality-of-

life measures, cost-data collection, and real-world evidence strategies. Ensure

evidence-generation plans anticipate future payer, reimbursement, and HTA

requirements

.

 Real-World Evidence & Outcomes Research: Analyze clinical-trial,

observational, and real-world datasets to evaluate healthcare resource utilization,

cost of care, treatment pathways, diagnostic utilization, clinical utility, comparative

effectiveness, patient outcomes, survival, budget impact, and quality-adjusted life

years. Translate findings into actionable evidence supporting clinical, payer, and

business decisions.

 Publication & Scientific Evidence Leadership: Lead HEOR publication

strategy and development of peer-reviewed manuscripts, scientific abstracts,

conference posters, oral presentations, white papers, and technical reports.

Coordinate publication plans and timelines with investigators, key opinion

leaders, academic collaborators, and external research partners to ensure

evidence generation is aligned with strategic business priorities.

 Market Access & Payer Evidence: Partner with Market Access, Medical Affairs,

Marketing, and Commercial teams to translate HEOR evidence into payer value

propositions, budget impact summaries, value dossiers, reimbursement

materials, health economic briefs, health-system value calculators, account-

specific economic tools, and other evidence-based value communications.

 Global HEOR Strategy: Develop and adapt health economic evidence and

payer models for the U.S. and international markets, including Europe, Japan,

Canada, Australia, and other priority geographies. Support reimbursement

submissions and evidence strategies aligned with HTA and payer requirements

across healthcare systems.

 Cross-Functional & External Collaboration: Serve as a strategic HEOR

partner across Medical Affairs, Clinical Development, Biostatistics, Market

Access, Commercial, Marketing, Regulatory, and Business Development.

Collaborate with external consultants, academic investigators, KOLs, and

research partners to execute high-quality evidence-generation initiatives.

Core Skills & Competencies

 Health Economics & Outcomes Research: Deep understanding of health

economic modeling, outcomes research, healthcare resource utilization, real-

world evidence, cost-of-care analysis, comparative effectiveness, and value

assessment methodologies.

 Economic Modeling: Demonstrated ability to develop and critically evaluate

budget impact, cost-effectiveness, cost-utility, ROI, decision-tree, Markov/state-

transition, and related economic models.

 Payer & Market Access Strategy: Strong understanding of payer evidence

requirements

and the ability to translate clinical and economic evidence into

compelling value propositions supporting reimbursement, coverage, and

adoption.

 Evidence Generation & Clinical Strategy: Ability to integrate HEOR endpoints

and evidence requirements into clinical development and real-world research

programs, anticipating future reimbursement and HTA needs.

 Scientific Communication & Publication: Strong scientific writing and

communication skills with experience translating complex analyses into

manuscripts, abstracts, presentations, value dossiers, p